Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)

The recombinant production, crystallization and high-resolution X-ray crystal structure of the isolated extracellular kringle domain of human receptor tyrosine kinase-like orphan receptor 1 are reported, together with its comparison with previously solved three-dimensional structures of other kringle domains and their complexes with antibody fragments.

Biochemical and crystallization analysis of the CENP-SX–DNA complex

CENP-SX is a histone-fold complex that is involved in chromosome segregation and DNA repair. Biochemical and crystallization analysis suggested that multiple molecules of CENP-SX may be involved in DNA binding.

Effects of the T337M and G391V disease-related variants on human phosphoglucomutase 1: structural disruptions large and small

Two variants of the enzyme PGM1 associated with human inherited disease were characterized, providing insights into their molecular pathomechanisms. Despite similar effects on protein stability and enzyme activity, crystal structures show diverse structural impacts due to the mutations.

Crystal structure of the PX domain of Vps17p from Saccharomyces cerevisiae

The crystal structure of the PX (phox homology) domain of the Saccharomyces cerevisiae Vps17p protein was determined. The absence of basic residues around the canonical binding site suggests an inability to bind phosphatidylinositol phosphate molecules.