issue contents
October 2024 issue
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Cover illustration: The crystal structure of the ternary complex of Plasmodium vivax N-myristoyltransferase with myristoyl-CoA and a novel inhibitor [Bolling et al. (2024), Acta Cryst. F80, 269–277]. The notable differences between this enzyme and the human enzyme can be exploited to develop new antimalarials.
editorial
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The Section Editors welcome and introduce three new Co-editors to the journal and summarize their expertise in computational structural biology, experimental structural biology and cryo-electron microscopy.
topical reviews
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An investigation of different types of glucose-6-phosphate dehydrogenase (G6PD) is reported, including NAD+- and NADP+-dependent G6PDs, fused glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase and bacterial F420-dependent G6PD. An extensive data-review tabulation of PDB entries is also provided for both X-ray crystal and electron cryo-microscopy structures.
research communications
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The DUF2436 domain of unknown function is highly conserved in virulence proteins from the pathogenic oral bacterium P. gingivalis. Theis domain exhibits a noncanonical β-jelly-roll sandwich topology with a previously unobserved fold consisting of two antiparallel β-sheets and one short α-helix.
PDB reference: PgDUF2436, 9isp
The B. pseudomallei protein BPSL0741, which has previously been identified to be essential for survival of the bacterium in an infected host, was successfully overexpressed in its recombinant form and purified to homogeneity. The recombinant protein appeared to be monomeric in solution and the protein crystal diffracted to 2.1 Å resolution.
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The 2.3 Å resolution ternary structure of the essential P. vivax N-myristoyltransferase with myristoyl-CoA and a peptide-binding domain inhibitor is reported as part of ongoing efforts by the SSGCID for the rational design of new therapeutics for malaria.
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Guanosine 5′-monophosphate (GMP) synthetase (GuaA) catalyzes the last step of GMP synthesis in the purine nucleotide biosynthetic pathway. In this study, the crystal structure of an XMP-bound form of GuaA from the thermophilic bacterium T. thermophilus HB8 was determined at a resolution of 2.20 Å and that of an apo form was determined at 2.10 Å resolution.