Structure of Clostridium leptum carboxyspermidine de­carboxylase and comparison to homologs prevalent within the human gut microbiome

A high-resolution structure of carboxyspermidine decarboxylase, a member of the PLP-dependent β/α-barrel-fold decarboxylase family, is analyzed.

Redox-dependent hydrogen-bond network rearrangement of ferredoxin–NADP⁺ reductase revealed by high-resolution X-ray and neutron crystallography

High-resolution X-ray and neutron crystallography reveal redox-dependent rearrangements in the hydrogen-bond network of ferredoxin–NADP⁺ reductase (FNR), highlighting structural changes around the FAD cofactor and shifts in water molecules that underpin its electron-transfer mechanism. These findings provide valuable insights into the functional modulation of FNR.

A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target

A versatile construct was designed to improve the purification yield and facilitate structural studies of the ligand-binding domain of the pregnane X receptor.

The first report of structural analysis of a nucleic acid using crystals grown in space

The first structural analysis of a nucleic acid using crystals obtained under microgravity crystallization in space is reported. A DNA/RNA heteroduplex was successfully crystallized in a microgravity environment, improving the size and appearance of the crystals compared with crystals obtained on Earth.

LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.

Crystal structure of di­hydroorotate de­hydrogenase from Helicobacter pylori with bound flavin mononucleotide

The crystal structure of dihydroorotate dehydrogenase from H. pylori bound to flavin mononucleotide was determined at 2.25 Å resolution in space group P2₁.

Cryo-EM structures of apo and atorvastatin-bound human 3-hy­droxy-3-methylglutaryl-coenzyme A reductase

Single-particle cryo-EM structures of apo and atorvastation-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase were determined using graphene oxide-coated grids.