June 2012 issue
Cover illustration: The compound brusatol, C26H32O11, is a natural product originally isolated from the seeds of Brucea sumatrana. It has also been isolated from the Chinese herbal medicine Brucea javanica and shown to have potent anticancer activity and antiviral activity against the tobaccomosaic virus. It is composed of an ,-unsaturated cyclohexanone ring, two cyclohexane rings, a six-membered lactone ring and a tetrahydrofuran ring. An intramolecular O-HO hydrogen bond occurs. In the crystal, O-HO hydrogen bonds link the molecules into helical chains propagating along . See: Hu, Jin, Yu, Tian & Jiang [Acta Cryst. (2012). E68, o1592-o1593].